Endocrine Abstracts

Systemic lupus erythematosus (SLE) is a disease that disproportionately affects females. We previously showed that a functional knockout of estrogen receptor alpha (ERαKO) resulted in significantly reduced renal disease and increased survival in murine lupus. The mechanism of this effect, which requires estrogen, is not known. Interestingly, an ERα−/− (null mutant) mouse is not similarly protected. We and others have demonstrated a role for ERα in de...